The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 25, 2023

Filed:

Jun. 21, 2022
Applicant:

Reviral Limited, Stevenage, GB;

Inventors:

George Stuart Cockerill, Stevenage, GB;

James Good, Stevenage, GB;

Edward James Cochrane, Nottingham, GB;

Assignee:

PFIZER INC., New York, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/5513 (2006.01); C07D 487/04 (2006.01); A61P 31/14 (2006.01); A61K 45/06 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/5513 (2013.01); A61K 45/06 (2013.01); A61P 31/14 (2018.01); C07D 519/00 (2013.01);
Abstract

Benzodiazepine derivatives of formula (I): (I) wherein: each of Rand Ris independently H or halo; either (i) T is N, Z is C, -a- and -c- are bonds, and -b- and -d- are absent; or (ii) T is C, Z is N, -b- and -d- are bonds, and -a- and -c- are absent; each of Rand Ris independently halo, —OR, —NRR—COR, —C(O)OR, —CON(R)or —R; Ris H or halo; each of Rand Ris independently H or a group selected from C-Calkyl, C-Ccycloalkyl, C6-C10 aryl, 4- to 10-membered heterocyclyl and 4- to 10-membered heteroaryl, the group being unsubstituted or substituted; Ris H or C-Calkyl, each Rbeing the same or different when two are present; n is 0 or 1; and one of V, W, X and Y is N or CH and the other three are CH; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.


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