The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 25, 2023

Filed:

May. 16, 2022
Applicant:

Array Biopharma Inc., Boulder, CO (US);

Inventors:

Patrick Michael Barbour, Westminster, CO (US);

Katie Keaton Brown, Niwot, CO (US);

Adam Wade Cook, Broomfield, CO (US);

Erik James Hicken, Longmont, CO (US);

Dean Russell Kahn, Longmont, CO (US);

Ellen Ruth Laird, Longmont, CO (US);

Andrew Terrance Metcalf, Erie, CO (US);

David Austin Moreno, Erie, CO (US);

Bradley Jon Newhouse, Broomfield, CO (US);

Spencer Phillip Pajk, Boulder, CO (US);

Brett Joseph Prigaro, Broomfield, CO (US);

Li Ren, Superior, CO (US);

Eugene Tarlton, Lafayette, CO (US);

Assignee:

Array BioPharma Inc., Boulder, CO (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 403/12 (2006.01); C07D 239/90 (2006.01); C07D 239/91 (2006.01); A61K 31/4184 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 403/12 (2013.01); C07D 239/90 (2013.01); C07D 239/91 (2013.01); A61K 31/4184 (2013.01); A61K 45/06 (2013.01);
Abstract

Provided herein are compounds of the Formula I: and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X, R, R, R, R, Rand Rare as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant and benign BRAF-associated tumors of the CNS and malignant extracranial BRAF-associated tumors.


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