The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 25, 2023
Filed:
May. 03, 2019
University of Maryland, Baltimore, Baltimore, MD (US);
The United States of America As Represented BY the Department of Veterans Affairs, Washington, DC (US);
Antonino Passaniti, White Hall, MD (US);
Alexander D. MacKerell, Jr., Baltimore, MD (US);
University of Maryland, Baltimore, Baltimore, MD (US);
The United States of America as Represented by the Department of Veterans Affairs, Washington, DC (US);
Abstract
Provide herein are compounds with a general chemical structure of: Substituents Rand Rindependently are H, Cl, F, Br, CH, CF, SH, —N(Calkyl), —NHC(O)Calkyl, or —NHC(O)Ccycloalkyl, substituent Ris H or Calkyl and R4 is a bridged cycloalkene such as a bridged cyclohexene or a bridge-substituted cyclohexene. The compounds are therapeutics to treat a cancer, such as breast cancer, or metastatic cancers, to inhibit RUNX2 activity, such as protein expression, in a cancer cell and to increase survival of a subject with breast cancer.