The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 25, 2023

Filed:

Mar. 06, 2018
Applicant:

Tei Biosciences, Inc., Boston, MA (US);

Inventors:

Kevin Cornwell, Holliston, MA (US);

Kenneth James, Barton, VT (US);

Assignee:

TEI BIOSCIENCES, INC., Boston, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61L 27/36 (2006.01); A61K 35/34 (2015.01); A61K 35/44 (2015.01); C12N 5/00 (2006.01); A61L 27/56 (2006.01); A61K 35/36 (2015.01); C12N 5/077 (2010.01);
U.S. Cl.
CPC ...
A61L 27/3604 (2013.01); A61K 35/34 (2013.01); A61K 35/36 (2013.01); A61K 35/44 (2013.01); A61L 27/3691 (2013.01); A61L 27/56 (2013.01); C12N 5/0068 (2013.01); A61L 27/3687 (2013.01); A61L 2430/40 (2013.01); C12N 5/0652 (2013.01); C12N 2533/54 (2013.01); C12N 2533/56 (2013.01); C12N 2533/90 (2013.01);
Abstract

A tissue graft for soft tissue repair or reconstruction comprising a sheet of a biopolymer-based matrix having a plurality of small perforations and a plurality of large perforations. The small perforations are sized to facilitate clotting and granulation tissue development within the perforations which, in turn, facilitates revascularization and cell repopulation in the patient. The large perforations are sized to reduce the occurrence of clotting and granulation tissue development within the perforations so that extravascular tissue fluids accumulating at the implant site can drain through the tissue graft. The large perforations enhance mammal tissue anchoring by permitting mammal tissue to compress into the perforations increasing mammal tissue contact area.


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