The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 25, 2023
Filed:
Nov. 22, 2018
Applicant:
Byondis B.v., Nijmegen, NL;
Inventors:
Vladimir Janousek, Bechovice, CZ;
Martin Kas, Bechovice, CZ;
Assignee:
Byondis B.V., Nijmegen, NL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61K 47/68 (2017.01); A61K 31/437 (2006.01); A61K 39/395 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6803 (2017.08); A61K 31/437 (2013.01); A61K 39/3955 (2013.01); C07D 471/04 (2013.01);
Abstract
The compound of formula (II) is an advantageous intermediate for improving the process of synthesizing the linker-drug vc-seco-DUBA, as well as for the overall process for preparing an antibody-drug conjugate comprising the vc-seco-DUBA linker-drug. The methods of making the compound of formula (II) can include recovery of the compound as a solid, such as via crystallization, in high yields and purity.