The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 25, 2023
Filed:
Jan. 08, 2021
Bright Peak Therapeutics Ag, Basel, CH;
Vijaya Raghavan Pattabiraman, Basel, CH;
Roberto Iacone, Basel, CH;
Jean-Philippe Carralot, Basel, CH;
Matilde Arévalo-Ruiz, Basel, CH;
Jeffrey William Bode, Basel, CH;
Alexander Mayweg, Basel, CH;
Fränzi Weibel, Basel, CH;
Anna Haydn, Basel, CH;
Régis Boehringer, Basel, CH;
Görkem Kurtuldu Sahin, Basel, CH;
Claudia Fetz, Basel, CH;
Camille Delon, Basel, CH;
Eric Armentani, Basel, CH;
Alexander Flohr, Basel, CH;
Giorgio Ottaviani, Basel, CH;
Bright Peak Therapeutics AG, Basel, CH;
Abstract
The present disclosure relates to modified IL-2 polypeptides, compositions comprising modified IL-2 polypeptides, methods of making the same, and methods of using the modified IL-2 polypeptides for treatment of diseases. In one aspect, the disclosure relates to the treatment of cancer using the modified IL-2 polypeptides. In some embodiments, the disclosed IL-2 polypeptides exhibit preferential binding characteristics to IL-2 receptor βγ complex (IL-2Rβ) over IL-2 receptor αβγ complex (IL-2Rα). In some embodiments, the molecular weight distribution of the modified IL-2 polypeptides is monodispersed.