The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 25, 2023
Filed:
Nov. 29, 2018
Applicant:
Suzhou Ribo Life Science Co., Ltd., Kunshan, CN;
Inventors:
Hongyan Zhang, Kunshan, CN;
Zhiwei Yang, Kunshan, CN;
Liqiang Cao, Kunshan, CN;
Liangyi Wan, Kunshan, CN;
Assignee:
SUZHOU RIBO LIFE SCIENCE CO., LTD., Jiangsu, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C12N 15/113 (2010.01); A61P 31/20 (2006.01); A61P 3/06 (2006.01); A61K 47/54 (2017.01); A61P 1/16 (2006.01); C07H 15/04 (2006.01);
U.S. Cl.
CPC ...
A61K 47/549 (2017.08); A61P 1/16 (2018.01); A61P 31/20 (2018.01); C07H 15/04 (2013.01); C12N 15/1131 (2013.01); C12N 15/1136 (2013.01); C12N 2310/14 (2013.01); C12N 2310/315 (2013.01); C12N 2310/3519 (2013.01);
Abstract
A compound for forming a conjugate with an active agent such as an oligonucleotide having a structure represented by Formula (321). The present disclosure also provides a corresponding conjugate. The conjugate of the present disclosure can specifically target hepatocytes, thereby effectively solve the problems associated with delivery of oligonucleotide drugs in vivo, and have low toxicity and excellent delivery efficiency while maintaining high stability for the delivered oligonucleotide.