The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 25, 2023

Filed:

Apr. 22, 2019
Applicant:

Hlb Pharmaceutical Co., Ltd, Namyangju-si, KR;

Inventors:

Sang Hwi Lee, Suwon-Si, KR;

Mijung Kim, Busan, KR;

Dooyong Jeong, Suwon-Si, KR;

Mi Jung Kim, Namyangju-Si, KR;

Wan Joo Kim, Seoul, KR;

So Kyoung Joo, Seongnam-Si, KR;

Assignee:

HLB PHARMACEUTICAL CO., LTD, Namyangju-si, KR;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/08 (2019.01); A61K 9/14 (2006.01); A61K 9/16 (2006.01); A61K 38/09 (2006.01);
U.S. Cl.
CPC ...
A61K 9/1682 (2013.01); A61K 9/1647 (2013.01); A61K 38/08 (2013.01); A61K 38/09 (2013.01);
Abstract

The present invention relates to a method for preparing biodegradable microspheres using a single-phase mixed solution containing water, alcohol, and dichloromethane. Provided is a method for preparing a biodegradable microsphere having a uniform drug loading efficiency by preparing and using a single-phase mixed solution in which no phase separation occurs without using a thickener and a surfactant. The preparation method of the present invention has the feature of keeping the content of a loaded drug uniform until a final biodegradable microsphere is prepared, by using a single-phase mixed solution in which no phase separation by a solvent occurs in the preparation process. Thus, the preparation method of the present invention is remarkably useful for the preparation of biodegradable microspheres.


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