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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11630052 B1

PDFFull Text
Date of Patent:
Apr. 18, 2023

Filed:

Sep. 11, 2020

Ultra-high throughput detection of fluorescent droplets using time domain encoded optofluidics

Applicant:

The Trustees of the University of Pennsylvania, Philadelphia, PA (US);

Inventors:

David A Issadore, Philadelphia, PA (US);

Venkata Yelleswarapu, Philadelphia, PA (US);

Assignee:

The Trustees of the University of Pennsylvania, Philadelphia, PA (US);

Attorney:

BakerHostetler

Primary Examiner:

Kiet T Nguyen

Int. Cl.
CPC ...
G01N 15/14 (2006.01); B01L 3/00 (2006.01); G01N 21/64 (2006.01); C12M 1/00 (2006.01); G01N 21/00 (2006.01); G06V 10/141 (2022.01); G06V 20/69 (2022.01); G01N 15/10 (2006.01); G01N 15/00 (2006.01); G01N 21/17 (2006.01);
U.S. Cl.
CPC ...
G01N 15/1434 (2013.01); B01L 3/502715 (2013.01); B01L 3/502784 (2013.01); C12M 1/00 (2013.01); G01N 15/14 (2013.01); G01N 15/1425 (2013.01); G01N 15/1429 (2013.01); G01N 15/1436 (2013.01); G01N 15/1459 (2013.01); G01N 15/1463 (2013.01); G01N 21/00 (2013.01); G01N 21/645 (2013.01); G06V 10/141 (2022.01); G06V 20/69 (2022.01); B01L 2200/0673 (2013.01); G01N 2015/0053 (2013.01); G01N 2015/1006 (2013.01); G01N 2015/144 (2013.01); G01N 2021/177 (2013.01); G01N 2021/1757 (2013.01); G01N 2021/1765 (2013.01); G01N 2201/0221 (2013.01); G01N 2201/0625 (2013.01); G01N 2201/0696 (2013.01);
Abstract

A high-throughput optofluidic device for detecting fluorescent droplets is disclosed. The device uses time-domain encoded optofluidics to detect a high rate of droplets passing through parallel microfluidic channels. A light source modulated with a minimally correlating maximum length sequences is used to illuminate the droplets as they pass through the microfluidic device. By correlating the resulting signal with the expected pattern, each pattern formed by passing droplets can be resolved to identify individual droplets.

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