The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 18, 2023
Filed:
Dec. 11, 2019
Applicant:
The United States of America,as Represented BY the Secretary,department of Health and Human Services, Bethesda, MD (US);
Inventors:
Alena Gros, Barcelona, ES;
Steven A. Rosenberg, Potomac, MD (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/06 (2006.01); C12N 5/0783 (2010.01); A61P 35/00 (2006.01); A61K 38/17 (2006.01); C12N 15/63 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0636 (2013.01); A61K 38/1703 (2013.01); A61P 35/00 (2018.01); C12N 15/63 (2013.01);
Abstract
Disclosed are methods of isolating T cells and TCRs having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation. Also disclosed are related methods of preparing a population of cells, populations of cells, TCRs, pharmaceutical compositions, and methods of treating or preventing cancer.