The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 18, 2023
Filed:
Dec. 19, 2019
Pfizer Inc., New York, NY (US);
Philip Ralph Dormitzer, Nyack, NY (US);
Ye Che, Niantic, CT (US);
Xiaoyuan Sherry Chi, Tenafly, NJ (US);
Seungil Han, Mystic, CT (US);
Kyle Paul Heim, Boulder, CO (US);
Thomas Richard Jones, Bluffton, SC (US);
Yuhang Liu, South Glastonbury, CT (US);
Xiayang Qiu, Mystic, CT (US);
Xinzhen Yang, Woodcliff, NJ (US);
Xiaojie Yao, East Lyme, CT (US);
Matthew Curtis Griffor, North Stonington, CT (US);
Jennifer Anne Nicki, Gales Ferry, CT (US);
Pfizer Inc., New York, NY (US);
Abstract
The present invention relates to polypeptides and cytomegalovirus (CMV) antigens that include at least one introduced amino acid mutation relative to the amino acid sequence of the wild-type HCMV glycoprotein B (gB). In some embodiments, the polypeptide is stabilized in a conformation alternative to the gB postfusion conformation. Also disclosed are compositions including the polypeptides and uses thereof.