The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 18, 2023
Filed:
Jan. 24, 2018
Beijing Shihong Pharmaceutical Research Center, Beijing, CN;
Junbo Zhang, Beijing, CN;
Xuran Zhang, Beijing, CN;
Qianqian Gan, Beijing, CN;
Xin Shao, Beijing, CN;
Xuebin Wang, Beijing, CN;
Zhigang Tang, Beijing, CN;
Jie Lu, Beijing, CN;
Zhanbin Zhang, Beijing, CN;
Beijing Shihong Pharmaceutical Research Center, Beijing, CN;
Abstract
ATc-labeled isonitrile-containing glucose derivative having the general formula [Tc-(CNDG)], preparation method and use thereof is disclosed herein. The derivative is centered onTc, and the carbon atom of the isonitrile in CNDG coordinates withTc(I) to form a hexacoordinated complex [Tc-(CNDG)]. The [Tc-(CNDG)]derivative was obtained by the synthesis of the ligand CNDG and the preparation of the lyophilized CNDG kit. The derivative of this disclosure has good stability, simple preparation, high uptake and good retention at a tumor site, and high tumor/non-target ratio, and it is a novelTc-labeled isonitrile-containing glucose derivative with excellent performance for tumor imaging. The derivative of this disclosure is advantageous for popularization and application.