The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 18, 2023

Filed:

Jun. 24, 2019
Applicants:

Galiana Technology Inc., San Diego, CA (US);

National Institutes of Health, Office of Technology Transfer, Rockville, MD (US);

Inventors:

Bruce T Hope, Ellicott City, MD (US);

Mark A Wells, San Diego, CA (US);

Gregory D Sutton, Del Mar, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61B 5/00 (2006.01); A61B 5/145 (2006.01); A61B 5/1473 (2006.01); A61B 5/07 (2006.01);
U.S. Cl.
CPC ...
A61B 5/4064 (2013.01); A61B 5/0031 (2013.01); A61B 5/076 (2013.01); A61B 5/1473 (2013.01); A61B 5/14546 (2013.01); A61B 5/6868 (2013.01); A61B 2560/0204 (2013.01); A61B 2562/028 (2013.01); A61B 2562/0285 (2013.01); Y10S 977/774 (2013.01);
Abstract

An intracellular monitoring device (IMD) that fits completely inside a living cell, and causes no significant impairment, to a cell's normal biological processes. The IMD monitors a cell for its level of a biological substance (e.g., calcium ion concentration) of interest. If the biological substance reaches or exceeds a threshold, the IMD transmits an electromagnetic signal, received by an antenna outside the cell. Each IMD has its electromagnetic signal encoded with a unique frequency. Detection of the frequency components, in the signals received by an antenna, permits identification of the source IMD's. A high calcium ion concentration is indicative of a strongly-activated cerebral cortex neuron. Brain tissue is relatively transparent to near infrared, making it a good frequency band, for the electromagnetic signals from neuron-monitoring IMD's. The near infrared of each IMD can be produced by quantum dots, powered by bioelectric catalysis triggered by high calcium ion concentration.


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