The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 2023
Filed:
Jun. 13, 2017
Applicant:
Grail, Llc, Menlo Park, CA (US);
Inventors:
Gordon Cann, Redwood City, CA (US);
Alex Aravanis, San Mateo, CA (US);
Arash Jamshidi, Menlo Park, CA (US);
Rick Klausner, Los Altos Hills, CA (US);
Richard Rava, Redwood City, CA (US);
Assignee:
GRAIL, LLC, Menlo Park, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/10 (2006.01); C12Q 1/6806 (2018.01); C12Q 1/6827 (2018.01); C12Q 1/6869 (2018.01); C12Q 1/6809 (2018.01); C12N 9/22 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1093 (2013.01); C12N 9/22 (2013.01); C12Q 1/6806 (2013.01); C12Q 1/6809 (2013.01); C12Q 1/6827 (2013.01); C12Q 1/6869 (2013.01); C12N 2310/20 (2017.05); C12N 2800/80 (2013.01);
Abstract
Provided herein are methods of enriching mutated cell free nucleic acids for detection and diagnosis of cancer. Also provided are methods using a CRISPR-Cas system to target and deplete unwanted more abundant cell free nucleic acid sequences thereby enriching for less abundant sequences.