The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 2023
Filed:
Jul. 09, 2018
Applicant:
Children's Medical Center Corporation, Boston, MA (US);
Inventor:
Markus H. Frank, Cambridge, MA (US);
Assignees:
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Children's Medical Center Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); A61K 35/36 (2015.01); C12N 5/0775 (2010.01); A61P 19/04 (2006.01); A61P 19/08 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0625 (2013.01); A61K 35/36 (2013.01); A61P 19/04 (2018.01); A61P 19/08 (2018.01); C12N 5/0668 (2013.01);
Abstract
The present invention is directed to purified preparations of dermal mesenchymal stem cells that are characterized by the cell surface expression of the ABCB5 P-glycoprotein. The cells may be used for any purpose that mesenchymal stem cells from other course are used. For instance they may be administered to treat an organ transplant recipient to improve allograft survival or as a treatment to patients with autoimmune diseases such as multiple sclerosis and rheumatoid arthritis.