The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 2023
Filed:
Aug. 14, 2018
Bristol-myers Squibb Company, Princeton, NJ (US);
Stanley R. Krystek, Jr., Ringoes, NJ (US);
Yong Zhang, West Windsor, NJ (US);
Gregory D. Vite, Titusville, NJ (US);
Arvind Rajpal, San Francisco, CA (US);
Chetana Rao-Naik, Walnut Creek, CA (US);
Paul E. Morin, Pennington, NJ (US);
Mohan Srinivasan, Cupertino, CA (US);
Zheng Lin, North Wales, PA (US);
Virginie Lafont, Lawrence Township, NJ (US);
Alla Pritsker, Morganville, NJ (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
A prodrugged antibody has a blocking moiety attached to a Cys on its heavy or light chain via a linker having a cleavable moiety. The blocking moiety inhibits binding of the antibody to its antigen. Cleavage of the cleavable moiety releases the blocking moiety and restores ability of the antibody to bind to its antigen.