The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 2023
Filed:
Oct. 03, 2018
Merck Patent Gmbh, Darmstadt, DE;
Gordana Wozniak-Knopp, Vienna, AT;
Florian Rüker, Vienna, AT;
Gerhard Stadlmayr, Vienna, AT;
Jakub Rybka, Poznan, PL;
Nicolas Rasche, Darmstadt, DE;
Stephan Dickgiesser, Darmstadt, DE;
MERCK PATENT GMBH, Darmstadt, DE;
Abstract
A specific antigen-binding member (ABM) comprising a specific antigen-binding moiety and an antibody Fc region comprising a CH2 domain, which is engineered for a cysteine substitution at position 108 and/or 113, wherein numbering is according to the IMGT, and wherein the antibody Fc region does not comprise an antigen-binding CH3 domain; and an ABM conjugate (ABMC) comprising the ABM and at least one heterologous molecule covalently conjugated to one or both of the cysteines at positions 108 and 113 of the CH2 domain.