The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 2023
Filed:
Feb. 28, 2019
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
The Regents of the University of California, Oakland, CA (US);
Kurt R. Brunden, Media, PA (US);
Virginia M. Y. Lee, Philadelphia, PA (US);
John Q. Trojanowski, Philadelphia, PA (US);
Carlo Ballatore, San Diego, CA (US);
Killian Oukoloff, San Diego, CA (US);
Amos B. Smith, III, Merion, PA (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
The present disclosure provides compounds of formula (I) or (II) or a pharmaceutically acceptable salt or stereoisomer thereof, wherein Rx-R8 are defined herein. Also provided are compositions comprising a compound described herein and a pharmaceutically effective excipient, methods of stabilizing microtubules in a patient comprising administering to the patient a microtubule-stabilizing amount of a compound described herein, methods of treating cancer in a patient comprising administering to the patient a therapeutically effective amount of a compound described herein, and methods of treating a neurodegenerative disease in a patient comprising administering to the patient a therapeutically effective amount of a compound described herein.