The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 2023
Filed:
May. 02, 2018
Axxam S.p.a., Bresso, IT;
Paolo Pevarello, Bresso, IT;
Mariangela Sodano, Bresso, IT;
Elda Severi, Bresso, IT;
Rocco Vitalone, Bresso, IT;
Russell Thomas, Bresso, IT;
Valentina Cusano, Bresso, IT;
BREYE THERAPEUTICS APS, Hørsholm, DK;
Abstract
Disclosed are compounds of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions containing them, and to a process for the preparation of the compounds: Ris independently selected from hydrogen atom, amine group, monocyclic or bicyclic aliphatic, aromatic, heteroaliphatic or heteroaromatic ring. Ris independently selected from monocyclic or bicylic aliphatic, heteroaliphatic, aromatic or heteroaromatic ring, C-Calkyl, alkenyl or alkynyl chain. n is 1 or 2; preferably n is 1. m is 0, 1 or 2; preferably m is 0. Rand Rcan be, independently, —H, —F, C-Calkyl, —OH, —OC-Calkyl; preferably they are both —H. X is O or S. Ris —H or —CHoptionally substituted by one or more fluorine atoms; preferably Ris hydrogen. The compounds can be used in the treatment of conditions or diseases mediated by P2X7 receptor.