The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 2023
Filed:
Jul. 13, 2020
Purdue Research Foundation, West Lafayette, IN (US);
University of Utah, Salt Lake City, UT (US);
Stewart Andrew Low, West Lafayette, IN (US);
Philip S. Low, West Lafayette, IN (US);
Christopher Galliford, Silver Spring, MD (US);
Jindrich Kopecek, Salt Lake City, UT (US);
Jiyan Yang, Salt Lake City, UT (US);
Purdue Research Foundation, West Lafayette, IN (US);
University of Utah, Salt Lake City, UT (US);
Abstract
Aspects of the present disclosure generally relate to compounds for targeting and healing bone fractures. Some of these compounds include a negatively charged oligopeptide comprising an acidic oligopeptide, a linker, which may be hydrolyzable or may be a substrate for the protease cathepsin K, and at least one molecule that promotes bone healing. In some compounds the molecule that promotes bone healing is an anabolic compound that inhibits GSK3β, in some compounds the molecule that promotes the healing of bone fracture is a pro-inflammatory agent such as PGE1. Other embodiments include methods of treating a bone fracture comprising administering a therapeutic amount of any one of the compounds disclosed herein.