The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 2023
Filed:
Jun. 05, 2020
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Qing Fang, Chappaqua, NY (US);
Chia-Jen Siao, New York, NY (US);
Dan Chalothorn, New York, NY (US);
KehDih Lai, Yardley, PA (US);
Leah Sabin, Goldens Bridge, NY (US);
Rachel Sattler, New York, NY (US);
Brian Zambrowicz, Sleepy Hollow, NY (US);
Lori Morton, Chappaqua, NY (US);
Regeneran Pharmaceuticals, Inc., Tarrytown, NY (US);
Abstract
Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized albumin (ALB) locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized albumin locus express a human albumin protein or a chimeric albumin protein, fragments of which are from human albumin. Methods are provided for using such non-human animals comprising a humanized albumin locus to assess in vivo efficacy of human-albumin-targeting reagents such as nuclease agents designed to target human albumin.