The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 04, 2023
Filed:
Sep. 12, 2019
Korea Institute of Science and Technology, Seoul, KR;
Seoul National University R&db Foundation, Seoul, KR;
Ick Chan Kwon, Seoul, KR;
Ju Hee Ryu, Seoul, KR;
Young-Ji Ko, Seoul, KR;
Hye-Sun Kim, Seoul, KR;
Nam-Hyuk Cho, Seoul, KR;
Eun-Jeong Yang, Seoul, KR;
Jae Won Lee, Daegu, KR;
Korea Institute of Science and Technology, Seoul, KR;
Seoul National University R&DB Foundation, Seoul, KR;
Abstract
A probe for measuring the activity of caspase-1 according to the present disclosure can specifically image cells or tissues where inflammatory response is induced because it is cleaved by reacting specifically with the active caspase-1 enzyme in vivo and in vitro and re-emits fluorescence. The probe for measuring the activity of caspase-1 can be used for various purposes, such as for imaging of cells or tissues where inflammatory response is induced, as a drug carrier, for screening of a drug inhibiting inflammatory response, etc. The probe for measuring the activity of caspase-1 is applicable both in vivo and in vitro, and can be used for various applications such as high-throughput screening for new drug development, early diagnosis of diseases, etc.