The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 04, 2023
Filed:
Oct. 11, 2019
Applicant:
Roche Diagnostics Operations, Inc., Indianapolis, IN (US);
Inventors:
Christian Helmut Bell, Basel, CH;
Harald Sobek, Biberach, DE;
Heiko Walch, Munich, DE;
Kiyoshi Yasukawa, Kyoto, JP;
Misato Baba, Hyto, JP;
Assignee:
Roche Diagnostics Operations, Inc., Indianapolis, IN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C12N 9/12 (2006.01); C12Q 1/68 (2018.01); C12P 19/34 (2006.01);
U.S. Cl.
CPC ...
C12N 9/1276 (2013.01); C12P 19/34 (2013.01); C12Q 1/68 (2013.01); C12Y 207/07049 (2013.01);
Abstract
The present invention relates to a mutant reverse transcriptase (RT) with increased thermal stability relative to the wildtype, a nucleic acid encoding the mutant RT, a cell comprising the mutant RT or the nucleic acid, a kit comprising the mutant RT, the use of the mutant RT for cDNA synthesis, method for reverse transcription of RNA comprising synthesizing cDNA with the use of the mutant RT and a method for detecting an RNA marker in a sample with the use of the mutant RT.