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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11618888 B1

PDFFull Text
Date of Patent:
Apr. 04, 2023

Filed:

Nov. 20, 2020

Tumor-selective e1a and e1b mutants

Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

Tony Reid, San Diego, CA (US);

Farah Hedjran, San Diego, CA (US);

Shantanu Kumar, San Diego, CA (US);

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);

Attorney:

Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.

Primary Examiner:

Bao Q Li

Int. Cl.
CPC ...
C12N 15/86 (2006.01); C12N 15/861 (2006.01); C12N 7/00 (2006.01); A61K 35/761 (2015.01); C07K 14/005 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
C12N 7/00 (2013.01); A61K 35/761 (2013.01); C07K 14/005 (2013.01); C12N 15/86 (2013.01); A61K 48/00 (2013.01); C12N 2710/10021 (2013.01); C12N 2710/10022 (2013.01); C12N 2710/10032 (2013.01); C12N 2710/10321 (2013.01); C12N 2710/10322 (2013.01); C12N 2710/10332 (2013.01); C12N 2710/10341 (2013.01); C12N 2710/10343 (2013.01); C12N 2830/00 (2013.01);
Abstract

Modified E1a regulatory sequences are provided, wherein at least one Pea3 binding site, or a functional portion thereof, is deleted. Also provided are modified E1a sequences that selectively express particular isoforms. Also provided is an E1b-19K clone insertion site. These modified sequences can be used individually, or in combination with one another, to provide tumor-selective expression of proteins.

Find Patent Forward Citations

Reid, Tony. (2023). Tumor-selective e1a and e1b mutants (U.S. Patent No. 11618888). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11618888

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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