The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 04, 2023
Filed:
Oct. 31, 2016
Applicants:
Cancer Research Technology Limited, London, GB;
King's College London, London, GB;
The Francis Crick Institute Limited, London, GB;
Inventors:
Assignees:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/17 (2015.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0638 (2013.01); C12N 2501/2302 (2013.01); C12N 2501/2315 (2013.01);
Abstract
This invention relates to the expansion of non-haematopoietic tissue-resident γδ T cells in vitro by culturing lymphocytes obtained from non-haematopoietic tissue of humans or non-human animals in the presence of interleukin-2 (IL-2) and/or interleukin-15 (IL-15) and the absence of TCR activation or co-stimulation signals, without any direct contact with stromal or epithelial cells. Methods of non-haematopoietic tissue-resident γδ T cell expansion are provided, as well as populations of non-haematopoietic tissue-resident γδ T cells and uses thereof.