The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 04, 2023
Filed:
Jul. 19, 2017
Applicant:
Teva Pharmaceuticals Australia Pty Ltd, New South Wales, AU;
Inventors:
Sarah Lee Pogue, Redwood City, CA (US);
David Scofield Wilson, Redwood City, CA (US);
Tetsuya Taura, Redwood City, CA (US);
Assignee:
Teva Pharmaceuticals Australia Pty Ltd., Macquarie Park, AU;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/21 (2006.01); C07K 16/28 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2803 (2013.01); A61K 38/212 (2013.01); A61P 35/00 (2018.01); C07K 16/2896 (2013.01);
Abstract
The present invention provides a combination therapy for treating a tumor in a subject. The combination comprises two elements. The first is a polypeptide construct comprising an attenuated Type 1 interferon (IFN) linked to an antibody which binds to a cell surface-associated antigen expressed on the tumour cell and comprising a functional Fc region. The second is a CD47 antagonist which inhibits the interaction CD47 with the SIRPα receptor.