The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 04, 2023
Filed:
Apr. 21, 2020
Applicant:
The United States of Americans Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Inventors:
Zhijian Wu, Gaithersburg, MD (US);
Anand Swaroop, Gaithersburg, MD (US);
Suja Hiriyanna, Boyds, MD (US);
Tiansen Li, Clarksburg, MD (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 38/17 (2006.01); A61P 27/02 (2006.01); C07K 14/00 (2006.01); C07K 14/47 (2006.01); C12N 15/86 (2006.01); C12N 15/864 (2006.01);
U.S. Cl.
CPC ...
A61K 48/005 (2013.01); A61K 38/1709 (2013.01); A61K 48/0058 (2013.01); C07K 14/4706 (2013.01); C12N 15/86 (2013.01); C12N 15/8645 (2013.01); C12N 2750/14143 (2013.01); C12N 2830/001 (2013.01); C12N 2830/008 (2013.01); C12N 2830/42 (2013.01); C12N 2830/50 (2013.01);
Abstract
Disclosed are adeno-associated virus (AAV) vectors comprising a nucleotide sequence encoding RP2 or RPGR-ORF15 and related pharmaceutical compositions. Also disclosed are methods of treating or preventing X-linked retinitis pigmentosa, increasing photoreceptor number in a retina of a mammal, and increasing visual acuity of a mammal using the vectors and pharmaceutical compositions.