The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 04, 2023
Filed:
Nov. 15, 2016
Applicant:
Research Institute AT Nationwide Children's Hospital, Columbus, OH (US);
Inventors:
Louise Rodino-Klapac, E. Groveport, OH (US);
Rachael Potter, Dublin, OH (US);
Assignee:
RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL, Columbus, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); A61K 38/39 (2006.01); C12N 9/22 (2006.01); C12N 15/90 (2006.01); A61K 48/00 (2006.01); C07K 14/47 (2006.01); C12N 15/88 (2006.01); C12N 15/113 (2010.01); A61P 21/00 (2006.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
A61K 38/39 (2013.01); A61K 48/00 (2013.01); A61K 48/005 (2013.01); A61P 21/00 (2018.01); C07K 14/4716 (2013.01); C12N 9/22 (2013.01); C12N 15/11 (2013.01); C12N 15/113 (2013.01); C12N 15/88 (2013.01); C12N 15/907 (2013.01); C12N 2310/20 (2017.05); C12N 2750/14143 (2013.01); C12N 2800/80 (2013.01);
Abstract
The present application provides materials and methods for treating a patient with a titin-based myopathy, particularly a titin-based cardiomyopathy, and/or other titinopathy. In addition, the present application provides materials and methods for editing the titin gene in a cell by genome editing.