The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 28, 2023

Filed:

Mar. 08, 2019
Applicant:

Baylor College of Medicine, Houston, TX (US);

Inventors:

Jian-Ming Lu, Pearland, TX (US);

Qizhi Yao, Houston, TX (US);

Changyi Chen, Houston, TX (US);

Assignee:

Baylor College of Medicine, Houston, TX (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C08G 81/00 (2006.01); C12N 15/88 (2006.01); A61K 48/00 (2006.01); C08G 81/02 (2006.01); C08G 63/91 (2006.01); C08G 63/685 (2006.01); C08G 73/02 (2006.01); A61K 47/60 (2017.01); A61K 47/59 (2017.01); A61K 47/69 (2017.01);
U.S. Cl.
CPC ...
C08G 81/00 (2013.01); A61K 47/59 (2017.08); A61K 47/593 (2017.08); A61K 47/60 (2017.08); A61K 47/6929 (2017.08); A61K 47/6935 (2017.08); A61K 47/6937 (2017.08); A61K 48/005 (2013.01); A61K 48/0041 (2013.01); C08G 63/6852 (2013.01); C08G 63/912 (2013.01); C08G 73/0206 (2013.01); C08G 81/027 (2013.01); C12N 15/88 (2013.01); C12N 2310/14 (2013.01); C12N 2310/141 (2013.01); C12N 2320/32 (2013.01);
Abstract

Embodiments of the invention concern copolymers and nanoparticles for use as delivery agents for one or more agents for therapy for a medical condition of humans and animals. Some of embodiments of the invention provide new reagents for biomedical research in cell culture, animal models and plants, for example. The copolymers comprise PLGA and PEI and, in some embodiments, also comprise 1-(3-aminopropyl)-4-methylpiperazine (APMP), Fc binding peptide and/or antibody. In certain embodiments, APMP-PLGA-PEI, Fc binding peptide/antibody-PLGA-PEI or Fc binding peptide/antibody-APMP-PLGA-PEI nanoparticles comprising one or more therapeutic agents are delivered to an individual in need thereof or used for biomedical research in cell cultures, animal models and plants.


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