The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 28, 2023
Filed:
Apr. 26, 2016
Applicant:
Autolus Limited, London, GB;
Inventors:
Martin Pulé, London, GB;
Shaun Cordoba, London, GB;
Assignee:
AUTOLUS LIMITED, London, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 7/08 (2006.01); C12N 5/0783 (2010.01); C07K 16/28 (2006.01); C07K 14/725 (2006.01); C07K 14/705 (2006.01); C07K 14/685 (2006.01); C12N 9/16 (2006.01);
U.S. Cl.
CPC ...
C07K 7/08 (2013.01); C07K 14/685 (2013.01); C07K 14/7051 (2013.01); C07K 14/70517 (2013.01); C07K 14/70521 (2013.01); C07K 14/70589 (2013.01); C07K 16/2803 (2013.01); C12N 5/0636 (2013.01); C12N 9/16 (2013.01); C12Y 301/03048 (2013.01); C07K 2317/622 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/30 (2013.01); C07K 2319/33 (2013.01); C07K 2319/50 (2013.01); C07K 2319/70 (2013.01); C12N 2510/00 (2013.01);
Abstract
The present invention provides a nucleic acid construct comprising the following structure: A-X-B in which A is nucleic acid sequence encoding a first polypeptide which comprises a first signal peptide; B is nucleic acid sequence encoding a second polypeptide which comprises a second signal peptide and X is a nucleic acid sequence which encodes a cleavage site, wherein the first signal peptide or the second signal peptide comprises one or more mutation(s) such that it has fewer hydrophobic amino acids.