The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 28, 2023
Filed:
Jan. 22, 2021
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
University of Maryland, Baltimore, Baltimore, MD (US);
Craig Thomas, Gaithersburg, MD (US);
Carlos Zarate, Germantown, MD (US);
Ruin Moaddel, Bel Air, MD (US);
Todd Gould, Elkridge, MD (US);
Panos Zanos, Baltimore, MD (US);
Patrick Morris, Columbia, MD (US);
Abstract
The disclosure provides a method for synthesizing free base forms of (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine. In an embodiment synthesis of (2R,6R)-hydroxynorketamine (HNK) includes preparation of (R)-norketamine via chiral resolution from racemic norketamine via a chiral resolution with L-pyroglutamic acid. The disclosure also provided crystal forms of the corresponding (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine hydrochloride salts.