The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 28, 2023

Filed:

Jan. 31, 2018
Applicant:

The Trustees of the Stevens Institute of Technology, Hoboken, NJ (US);

Inventors:

Hongjun Wang, Millburn, NJ (US);

Meng Xu, Secaucus, NJ (US);

Deep Parikh, South Plainfield, NJ (US);

Jin Zou, Rutherford, NJ (US);

Weiwei Wang, Jersey City, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61L 27/36 (2006.01); A61L 27/56 (2006.01); G01N 33/50 (2006.01); C12N 5/00 (2006.01); A61L 27/54 (2006.01); A61L 27/18 (2006.01); A61L 27/52 (2006.01); A61L 27/58 (2006.01); A61L 27/60 (2006.01);
U.S. Cl.
CPC ...
A61L 27/3691 (2013.01); A61L 27/18 (2013.01); A61L 27/3604 (2013.01); A61L 27/365 (2013.01); A61L 27/3608 (2013.01); A61L 27/3666 (2013.01); A61L 27/52 (2013.01); A61L 27/54 (2013.01); A61L 27/56 (2013.01); A61L 27/58 (2013.01); A61L 27/60 (2013.01); C12N 5/0062 (2013.01); C12N 5/0075 (2013.01); G01N 33/5011 (2013.01); G01N 33/5082 (2013.01); A61L 2430/02 (2013.01); A61L 2430/28 (2013.01); C12N 2500/84 (2013.01); C12N 2503/02 (2013.01); C12N 2513/00 (2013.01); C12N 2533/00 (2013.01); C12N 2533/30 (2013.01); C12N 2533/74 (2013.01); C12N 2539/00 (2013.01);
Abstract

3D native tissue-derived scaffolding materials are made in various formats, including but not limited to hydrogel, sponge, fibers, microspheres, and films, all of which function to better preserve natural extracellular matrix molecules and to recapitulate the natural tissue environment, thereby effectively guiding tissue regeneration. Tissue-derived scaffolds are prepared by incorporating a homogenized tissue-derived suspension into a polymeric solution of synthetic, natural, or hybrid polymers. Such tissue-derived scaffolds and scaffolding materials have a variety of utilities, including: the creation of 3D tissue models such as skin, bone, liver, pancreas, lung, and so on; facilitation of studies on cell-matrix interactions; and the fabrication of implantable scaffolding materials for guided tissue formation in vivo. The tissue-derived scaffolds and scaffolding materials also provide the opportunity to correlate the functions of extracellular matrix with tissue regeneration and cancer metastasis, for example.


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