The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 28, 2023
Filed:
Oct. 02, 2020
The Regents of the University of California, Oakland, CA (US);
Purdue Research Foundation, West Lafayette, IN (US);
Alyssa Panitch, Oakland, CA (US);
Emily Michelle Misnick, Oakland, CA (US);
Jenny B. Lin, Oakland, CA (US);
Kit S. Lam, Davis, CA (US);
Ruiwu Liu, Oakland, CA (US);
Dake Hao, Oakland, CA (US);
Aijun Wang, Sacramento, CA (US);
The Regents of the University of California, Oakland, CA (US);
Purdue Research Foundation, West Lafayette, IN (US);
Abstract
The present disclosure provides pro-angiogenic proteoglycan mimetics that can provide a provisional, pro-angiogenic scaffold to support tissue regeneration while limiting systemic exposure to VEGF activity. These mimetics can protect a collagen matrix from rapid degradation, and in conjunction with EPCs promote angiogenesis in order to accelerate ischemic wound healing. For example, the provided compounds can be delivered from the end of a catheter following balloon angioplasty to coat the collagen exposed areas, prevent platelet binding and thrombosis, support capture of EPCs from blood to facilitate reendothelialization, and reduce late-lumen loss (neointimal hyperplasia).