The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 28, 2023

Filed:

Jan. 16, 2017
Applicants:

Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechts, Heidelberg, DE;

Eberhard Karls Universität Tübingen, Tübingen, DE;

Inventors:

Helmut Salih, Stuttgart, DE;

Fabian Vogt, Tübingen, DE;

Gundram Jung, Rottenburg, DE;

Latifa Zekri-Metref, Tübingen, DE;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/28 (2006.01); A61K 39/00 (2006.01); C07K 16/30 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/001195 (2018.08); A61K 39/001194 (2018.08); A61P 35/00 (2018.01); C07K 16/2809 (2013.01); C07K 16/3069 (2013.01); C07K 16/3084 (2013.01); A61K 2039/572 (2013.01); A61K 2039/884 (2018.08); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/55 (2013.01); C07K 2317/622 (2013.01); C07K 2317/73 (2013.01);
Abstract

The present invention provides a novel PSMA binding antibody termed 10B3 and pharmaceutical and diagnostic uses of the antibody 10B3. The PSMA antibody 10B3 does not cross-compete with the state of the art PMSA binding antibody J591 and has a reduced induction of antigen shift compared to J591 and a unique reactivity with squamous cell carcinoma (SCC) cells of different origin.


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