The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 28, 2023
Filed:
Dec. 13, 2021
Pharmaceutical composition and method for relieving/eliminating morphine-induced analgesic tolerance
Xuzhou Medical University, Xuzhou, CN;
Qiongyao Tang, Xuzhou, CN;
Zhe Zhang, Xuzhou, CN;
Chen Chen, Xuzhou, CN;
Mingxi Tang, Xuzhou, CN;
Yue Teng, Xuzhou, CN;
Nan Zhou, Xuzhou, CN;
Shaoxi Ke, Xuzhou, CN;
Ping Dong, Xuzhou, CN;
Jingjing Wang, Xuzhou, CN;
Wanxin Su, Xuzhou, CN;
Xiaohui Wang, Xuzhou, CN;
Yanmei Xiao, Xuzhou, CN;
Su Liu, Xuzhou, CN;
Long Ma, Xuzhou, CN;
Jun Gan, Xuzhou, CN;
Xiaoxia Zhu, Xuzhou, CN;
Sibei Ruan, Xuzhou, CN;
Feng Ling, Xuzhou, CN;
XUZHOU MEDICAL UNIVERSITY, Xuzhou, CN;
Abstract
Disclosed are a pharmaceutical composition and method for relieving/eliminating morphine-induced analgesic tolerance. The pharmaceutical composition includes a therapeutically effective amount of a short peptide and morphine as active ingredients, and a pharmaceutically-acceptable carrier. The short peptide is a peptide consisting of an amino acid sequence shown in SEQ ID NO: 1 or a pharmaceutically-acceptable salt thereof. In the method, the short peptide and morphine are administered to a subject simultaneously; or the short peptide is injected to the subject followed by administration of the morphine; or a pharmaceutical composition including the short peptide and morphine is administered to the subject.