The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 28, 2023
Filed:
Oct. 03, 2019
Genentech, Inc., South San Francisco, CA (US);
Jun Liang, Los Altos Hills, CA (US);
Rohan V. Mendonca, Pleasanton, CA (US);
Michael Siu, San Francisco, CA (US);
John Tellis, San Mateo, CA (US);
Weiru Wang, Orinda, CA (US);
BinQing Wei, Belmont, CA (US);
Bryan Chan, Foster City, CA (US);
Edna F. Choo, San Francisco, CA (US);
Joy Drobnick, Daly City, CA (US);
Lewis J. Gazzard, Belmont, CA (US);
Timothy Heffron, Burlingame, CA (US);
Genentech, Inc., South San Francisco, CA (US);
Abstract
3-Carbonylamino-8-aminoisoquinoline compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the 3-carbonylamino-8-aminoisoquinoline compounds.