The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 28, 2023
Filed:
Sep. 20, 2018
Applicant:
Thiogenesis Therapeutics, Inc., San Diego, CA (US);
Inventors:
Vincent P. Stanton, Jr., Belmont, MA (US);
Patrice P. Rioux, San Diego, CA (US);
Piotr Barski, Sopot, PL;
Dariusz Witt, Gdansk, PL;
Assignee:
Thiogenesis Therapeutics, Inc., San Diego, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/16 (2006.01); A61K 31/145 (2006.01); A61K 9/00 (2006.01); A61K 45/06 (2006.01); C07C 319/18 (2006.01);
U.S. Cl.
CPC ...
A61K 31/16 (2013.01); A61K 9/009 (2013.01); A61K 31/145 (2013.01); A61K 45/06 (2013.01); C07C 319/18 (2013.01);
Abstract
The invention features methods for the treatment of cystinosis and other cysteamine sensitive disorders in a subject including administration of a disulfide convertible to cysteamine in vivo. The methods can include the separate administration of a reducing agent to the subject to increase the bioavailablity and extend the plasma pharmacokinetic profile of the cysteamine produced following administration of the disulfide. The methods permit sustained cysteamine plasma concentrations in a subject.