The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 28, 2023
Filed:
Dec. 30, 2019
Applicant:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Inventors:
Lynn Macdonald, Harrison, NY (US);
Cagan Gurer, Chappaqua, NY (US);
Karolina A. Hosiawa, Yorktown Heights, NY (US);
Sean Stevens, Del Mar, CA (US);
Andrew J. Murphy, Croton-on-Hudson, NY (US);
Assignee:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A01K 67/027 (2006.01); C07K 16/46 (2006.01); C12N 9/64 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0278 (2013.01); C07K 16/2866 (2013.01); C07K 16/462 (2013.01); C12N 9/6489 (2013.01); A01K 2217/072 (2013.01); A01K 2217/15 (2013.01); A01K 2227/105 (2013.01); A01K 2267/01 (2013.01); C12N 2800/204 (2013.01); C12N 2800/30 (2013.01);
Abstract
Non-human animals, tissues, cells, and genetic material are provided that comprise a modification of an endogenous non-human heavy chain immunoglobulin sequence and that comprise an ADAM6 activity functional in a mouse, wherein the non-human animals express a human immunoglobulin heavy chain variable domain and a cognate human immunoglobulin λ light chain variable domain.