The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 28, 2023
Filed:
Oct. 19, 2018
Applicant:
Denali Therapeutics Inc., South San Francisco, CA (US);
Inventors:
Mark S. Dennis, South San Francisco, CA (US);
Adam P. Silverman, South San Francisco, CA (US);
Joy Yu Zuchero, South San Francisco, CA (US);
Assignee:
Denali Therapeutics Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01K 67/027 (2006.01); C07K 14/705 (2006.01); G01N 33/53 (2006.01); G01N 33/50 (2006.01); C07K 14/79 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0278 (2013.01); A01K 67/0275 (2013.01); C07K 14/705 (2013.01); C07K 14/70582 (2013.01); C07K 14/79 (2013.01); G01N 33/5088 (2013.01); G01N 33/5308 (2013.01); G01N 33/68 (2013.01); A01K 2217/00 (2013.01); A01K 2217/072 (2013.01); A01K 2217/075 (2013.01); A01K 2227/105 (2013.01); A01K 2267/03 (2013.01); C07K 2319/00 (2013.01); G01N 2500/10 (2013.01);
Abstract
In some aspects, the present invention provides chimeric transferrin receptor (TfR) polynucleotides and polypeptides. In other aspects, this invention provides chimeric TfR transgenic animal models and methods of using the animal models to identify therapeutics that can cross the blood-brain barrier.