The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 21, 2023

Filed:

Aug. 21, 2018
Applicant:

The General Hospital Corporation, Boston, MA (US);

Inventors:

Yosef E. Maruvka, Boston, MA (US);

Gad Getz, Boston, MA (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G16B 20/00 (2019.01); C12Q 1/6886 (2018.01); G16B 40/20 (2019.01); G16B 50/00 (2019.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); G16B 20/00 (2019.02); G16B 40/20 (2019.02); G16B 50/00 (2019.02); C12Q 2600/106 (2013.01); C12Q 2600/156 (2013.01);
Abstract

The present disclosure relates to detecting microsatellite indels in cancer patients and those at high risk for cancer, and is useful for early detection of specific types of cancer and early onset of relapse. More particularly, the present disclosure relates to compositions, methods, and kits for classifying and treating neoplasia and tumors with microsatellite instability. The instant classifier identifies preferred therapeutic options, including combination therapies, for MSI tumor or cancer, and is particularly useful for patient stratification so that patients who would be treatable by immunotherapy drugs may be identified at a very low cost.


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