The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 21, 2023

Filed:

Mar. 21, 2022
Applicant:

Cambridge Epigenetix Limited, Saffron Walden, GB;

Inventors:

Shankar Balasubramanian, Cambridge, GB;

Jens Fullgrabe, Great Chesterford, GB;

Walraj Singh Gosal, Cambridge, GB;

Joanna Dawn Holbrook, London, GB;

Sidong Liu, Saffron Walden, GB;

David Morley, St. Albans, GB;

Oliver Nentwich, Cambridge, GB;

Tobias Ost, Ely, GB;

Michael Steward, Royston, GB;

Albert Vilella, Cambridge, GB;

Nicolas James Walker, Cambridge, GB;

Shirong Yu, Cambridge, GB;

Helen Rachel Bignell, Cambridge, GB;

Rita Santo San-Bento, Lyons, FR;

Assignee:

Cambridge Epigenetix Limited, Saffron Walden, GB;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6827 (2018.01); C12Q 1/6806 (2018.01); C12Q 1/6869 (2018.01); C12N 15/10 (2006.01); C12N 15/52 (2006.01); C12Q 1/6811 (2018.01); C12Q 1/686 (2018.01);
U.S. Cl.
CPC ...
C12Q 1/6827 (2013.01); C12N 15/1058 (2013.01); C12N 15/52 (2013.01); C12Q 1/686 (2013.01); C12Q 1/6806 (2013.01); C12Q 1/6811 (2013.01); C12Q 1/6869 (2013.01);
Abstract

Provided herein are methods, systems, and compositions for determining a base in a polynucleotide. In various aspects, the methods, systems, and compositions presented herein are useful for performing 4-base, 5-base, or 6-base sequencing of polynucleotide molecules, for example, from liquid biopsy samples or wherein the base is a low frequency mutation.


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