The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 21, 2023
Filed:
Mar. 29, 2019
Applicant:
The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);
Inventors:
Katja Pekrun, Palo Alto, CA (US);
Mark A. Kay, Los Altos, CA (US);
Assignee:
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); C07K 14/015 (2006.01); A61K 47/69 (2017.01); C07K 14/075 (2006.01); C12N 15/10 (2006.01); C12N 7/00 (2006.01); C12N 15/90 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 47/6901 (2017.08); C07K 14/015 (2013.01); C07K 14/075 (2013.01); C12N 15/102 (2013.01); C12N 7/00 (2013.01); C12N 15/902 (2013.01); C12N 2710/10041 (2013.01); C12N 2710/10071 (2013.01); C12N 2710/10134 (2013.01); C12N 2710/10141 (2013.01); C12N 2750/14123 (2013.01);
Abstract
The present invention relates to variant AAV capsid polypeptides, wherein the variant AAV capsid polypeptides exhibit increased transduction and/or tropism in human pancreatic tissue or human islets as compared non-variant parent capsid polypeptides.