The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 21, 2023
Filed:
Oct. 07, 2020
Applicant:
The Regents of the University of Michigan, Ann Arbor, MI (US);
Inventors:
Christopher Emil Whitehead, Ann Arbor, MI (US);
Judith S. Leopold, Ann Arbor, MI (US);
Assignee:
The Regents of the University of Michigan, Ann Arbor, MI (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 45/06 (2006.01); A61P 35/04 (2006.01); A61K 31/517 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01); C07D 413/14 (2006.01); C07D 471/04 (2006.01); A61K 31/4706 (2006.01); A61K 31/4709 (2006.01); A61K 31/5377 (2006.01);
U.S. Cl.
CPC ...
A61K 31/517 (2013.01); A61K 31/4706 (2013.01); A61K 31/4709 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); A61P 35/04 (2018.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/14 (2013.01); C07D 413/14 (2013.01); C07D 471/04 (2013.01);
Abstract
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a quinazoline structure or a quinoline structure which function as dual inhibitors of EGFR proteins and PI3K proteins, and their use as therapeutics for the treatment of cancer and other diseases.