The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 14, 2023

Filed:

Mar. 27, 2020
Applicant:

Agilent Technologies, Inc., Santa Clara, CA (US);

Inventors:

Xiao Xu, San Diego, CA (US);

Yama A. Abassi, San Diego, CA (US);

Xiaobo Wang, San Diego, CA (US);

Jiangbo Gan, San Diego, CA (US);

Assignee:

Agilent Technologies, Inc., Santa Clara, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/68 (2006.01); C12M 1/12 (2006.01); C12M 1/34 (2006.01); G01N 33/50 (2006.01); G01N 33/483 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6854 (2013.01); C12M 25/08 (2013.01); C12M 41/36 (2013.01); G01N 33/4836 (2013.01); G01N 33/5005 (2013.01); G01N 2500/10 (2013.01);
Abstract

Methods for identifying compounds that modulate cellular responses stimulated by IgE, which include providing an impedance-based system that monitors cell-substrate impedance of cells on a substrate; introducing cells to the substrate of the system; adding at least one test compound and IgE to the cells, wherein the at least one test compound is suspected of modulating cell responses stimulated by the IgE; adding an antigen to the cells; monitoring the cell-substrate impedance of cells on the substrate; and analyzing the cell-substrate impedance to evaluate whether the at least one test compound alters a cellular response to stimulation with the IgE.


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