The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 14, 2023
Filed:
Jun. 14, 2019
Roche Sequencing Solutions, Inc., Pleasanton, CA (US);
Ventana Medical Systems, Inc., Tucson, AZ (US);
Nelson R. Alexander, Marana, AZ (US);
Aoune Barhoumi, Oro Valley, AZ (US);
Jan Berka, Pleasanton, CA (US);
Rui Chen, Fremont, CA (US);
Lisa L. Gallegos, Tucson, AZ (US);
Toumy Guettouche, Pleasanton, CA (US);
Seoyoung Kim, Foster City, CA (US);
Maeve E. O'Huallachain, Belmont, CA (US);
Sedide Ozturk, Pleasanton, CA (US);
Jigar Patel, Verona, WI (US);
Florian Rubelt, Menlo Park, CA (US);
Stacey Stanislaw, Tucson, AZ (US);
ROCHE SEQUENCING SOLUTIONS, INC., Pleasanton, CA (US);
VENTANA MEDICAL SYSTEMS, INC., Oro Valley, AZ (US);
Abstract
The invention is a method of identifying a cognate antigen for a T-cell receptor using neoantigens from a patient's tumor cells combined with the patient's T-cells and using cell sorting, genome sequencing, expressing TCR genes, presenting tumor neoantigens on MHC complex and uniquely barcoding the T-cells where TCR recognition occurs to tag all components of the TCR recognition complex.