The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 14, 2023
Filed:
Aug. 13, 2019
Applicant:
Janssen Vaccines & Prevention B.v., Leiden, NL;
Inventors:
Assignee:
JANSSEN VACCINES & PREVENTION B.V., Leiden, NL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/12 (2006.01); C07K 14/005 (2006.01);
U.S. Cl.
CPC ...
C07K 14/005 (2013.01); A61K 39/12 (2013.01); C12N 2760/14022 (2013.01); C12N 2760/14034 (2013.01); C12N 2760/14051 (2013.01); C12N 2760/14122 (2013.01); C12N 2760/14134 (2013.01); C12N 2760/14151 (2013.01); C12N 2760/14222 (2013.01); C12N 2760/14234 (2013.01); C12N 2760/14251 (2013.01);
Abstract
Filovirus glycoprotein mutations that stabilize the trimeric form of the glycoprotein are provided. The Filovirus glycoproteins have certain amino acid substitutions at specified positions in the glycoprotein sequence. The Filovirus glycoproteins described herein have an improved percentage of trimer formation and/or an improved trimer yield as compared to a Filovirus glycoprotein that does not have one or more of the indicated amino acid substitutions. Also provided are nucleic acid molecules and vectors encoding the Filovirus glycoproteins, as well as compositions containing the Filovirus glycoproteins, nucleic acid, and vectors.