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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11603387 B1

PDFFull Text
Date of Patent:
Mar. 14, 2023

Filed:

Jan. 23, 2015

Socs mimetics for the treatment of diseases

Applicant:

University of Florida Research Foundation, Inc., Gainesville, FL (US);

Inventors:

Howard M. Johnson, Gainesville, FL (US);

Joseph Larkin, Gainesville, FL (US);

Chulbul M. Ahmed, Gainesville, FL (US);

Lindsey Jager, Madison, WI (US);

Assignee:

University of Florida Research Foundation, Inc., Gainesville, FL (US);

Attorney:

Saliwanchik, Lloyd & Eisenschenk

Primary Examiner:

Thea D' Ambrosio

Int. Cl.
CPC ...
C07K 7/00 (2006.01); C07K 14/00 (2006.01); A61K 38/17 (2006.01); C07K 7/08 (2006.01); A61K 45/06 (2006.01); A61K 9/127 (2006.01); A61K 31/138 (2006.01); A61K 31/7048 (2006.01); A61K 31/337 (2006.01); A61K 31/513 (2006.01); A61K 31/475 (2006.01); A61K 31/506 (2006.01); A61K 31/4745 (2006.01); A61K 31/704 (2006.01); C07K 14/47 (2006.01); A61K 31/675 (2006.01); C12Q 1/6883 (2018.01); A61K 38/10 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
C07K 7/08 (2013.01); A61K 9/127 (2013.01); A61K 31/138 (2013.01); A61K 31/337 (2013.01); A61K 31/475 (2013.01); A61K 31/4745 (2013.01); A61K 31/506 (2013.01); A61K 31/513 (2013.01); A61K 31/675 (2013.01); A61K 31/704 (2013.01); A61K 31/7048 (2013.01); A61K 38/10 (2013.01); A61K 38/17 (2013.01); A61K 45/06 (2013.01); C07K 14/4718 (2013.01); C12Q 1/6883 (2013.01); A61K 9/0014 (2013.01); C12Q 2600/158 (2013.01);
Abstract

The subject invention concerns peptide mimetics of SOCS proteins and methods of use. In one embodiment, a peptide mimetic of the invention binds to a SOCS1 and a SOCS3 target protein. In a specific embodiment, a peptide mimetic of the invention comprises the amino acid sequence of SEQ ID NO:1 and/or SEQ ID NO:2 and/or SEQ ID NO:51, or a functional fragment or variant thereof. In a further embodiment, a peptide of the invention can comprise multiple copies of the mimetic sequence. In one embodiment, a peptide of the invention comprises two or more copies of SEQ ID NO:1 and/or SEQ ID NO:2 and/or SEQ ID NO:51. In a specific embodiment, a peptide mimetic of the invention comprises the amino acid sequence of SEQ ID NO:3 and/or SEQ ID NO:4 to and/or SEQ ID NO:52, or a functional fragment or variant thereof. The subject invention also pertains to methods of treating and/or preventing autoimmune conditions and/or disorders. In one embodiment, one or more peptide mimetics of the invention are used to treat an autoimmune condition or disorder in a person or animal. In a specific embodiment, a mimetic of the invention is used to treat SLE in a person or animal. The subject invention also concerns methods for diagnosing and/or monitoring progression of SLE in a person or animal.

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