The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 14, 2023
Filed:
Mar. 28, 2018
Astex Therapeutics Limited, Cambridge, GB;
Cancer Research Technology Limited, London, GB;
Steven Howard, Cambridge, GB;
Jeffrey David St. Denis, Cambridge, GB;
Charlotte Mary Griffiths-Jones, Cambridge, GB;
Steven Douglas Hiscock, Royston, GB;
Alan Richard Burns, Loughborough, GB;
David Cousin, Nottingham, GB;
Kim Louise Hirst, Saffron Walden, GB;
James Daniel Osborne, Cambridge, GB;
Jonas Calleja Priede, Cambridge, GB;
Aaron Michael Dumas, Stevenage, GB;
Brian Christopher Bishop, Harlow, GB;
David Parry-Jones, Welwyn Garden, GB;
Jeremy Peter Scott, Hertford, GB;
Meenakshi Sundaram Shanmugham, London, GB;
Peter Richard Mullens, Welwyn Garden, GB;
Darren James Dixon, Oxford, GB;
Matthew James Gaunt, Cambridge, GB;
ASTEX THERAPEUTICS LIMITED, Cambridge, GB;
CANCER RESEARCH TECHNOLOGY LIMITED, London, GB;
Abstract
The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.