The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 14, 2023
Filed:
Apr. 12, 2021
Applicant:
Certa Therapeutics Pty Ltd, Melbourne, AU;
Inventors:
Thomas Miller, Wakefield, MA (US);
Nikolaos Papaioannou, Newton, MA (US);
Assignee:
Certa Therapeutics Pty Ltd, Melbourne, AU;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 213/06 (2006.01); C07C 235/38 (2006.01); C07C 255/60 (2006.01); C07D 215/08 (2006.01); C07D 231/56 (2006.01); C07D 233/58 (2006.01); C07D 241/42 (2006.01); C07D 249/08 (2006.01); C07D 257/04 (2006.01); C07D 265/34 (2006.01); C07D 271/10 (2006.01); C07D 305/08 (2006.01); C07D 307/06 (2006.01);
U.S. Cl.
CPC ...
C07C 235/38 (2013.01); C07C 255/60 (2013.01); C07D 213/06 (2013.01); C07D 215/08 (2013.01); C07D 231/56 (2013.01); C07D 233/58 (2013.01); C07D 241/42 (2013.01); C07D 249/08 (2013.01); C07D 257/04 (2013.01); C07D 265/34 (2013.01); C07D 271/10 (2013.01); C07D 305/08 (2013.01); C07D 307/06 (2013.01);
Abstract
Provided herein are anti-fibrotic compounds, in particular those of Formula (I), that inhibit the TGF-beta signaling pathway. Also provided are pharmaceutical compositions comprising the anti-fibrotic compounds, and methods of treating diseases or conditions associated with fibrosis, inflammation, and benign or malignant neoplastic diseases in a subject by administering a compound or composition described herein.