The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 14, 2023
Filed:
Aug. 31, 2021
Applicant:
Ankh Life Sciences Limited, Dublin, IE;
Inventors:
Gene H. Zaid, Hutchinson, KS (US);
Brian Scott Johnathan Blagg, Niles, MI (US);
Cameron E. West, Hutchinson, KS (US);
Assignee:
Ankh Life Sciences Limited, Dublin, IE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 39/15 (2006.01); C07C 49/747 (2006.01);
U.S. Cl.
CPC ...
C07C 39/15 (2013.01); C07C 49/747 (2013.01);
Abstract
Novel compounds which inhibit DYRK1A activity comprise thymoquinone derivatives including a pair of substituted or unsubstituted six-membered carbon rings selected from phenyl and cyclohexadiene linked by an alkyl or alkenyl linker. Each six-membered ring includes at least one oxygen-bearing substituent selected from carbonyl oxygens, hydroxyls, alkoxyls, and halogenated derivatives thereof. The compounds can be administered to mammalian subjects for inhibition of DYRK1A kinase proteins.